Myeloperoxidase deficiency attenuates systemic and dietary iron-induced adverse effects

Myeloperoxidase deficiency attenuates lipopolysaccharide-induced acute lung inflammation and subsequent cytokine and chemokine production.

Lung neutrophilia is common to a variety of lung diseases. The production of reactive oxygen and nitrogen species during neutrophil oxidative burst has been associated with protein and DNA damage. Myeloperoxidase (MPO) is an enzyme stored in the azurophilic granula of neutrophils. It is important in host defense because it generates the reactive oxidant hypochlorous acid and has been described ...

cannabis consumption systemic adverse effects

Dietary deficiency of iron--an extreme example.

Iron deficiency anaemia is still a problem in childhood, and even mild anaemia may interfere with psychomotor development. Occasionally, very severe anaemia is seen in paediatric wards. We present an extreme example of anaemia secondary to dietary deficiency of iron. CASE REPORT: A three and a half year old girl was admitted with lethargy and extreme pallor. The history was of increasing lethar...

Muscle specific iron deficiency has systemic consequences

Iron is an essential element for most prokaryotes and all eukaryotes. the skeletal muscle specific actin promoter driving the Cre recombinase Iron is required for heme synthesis, iron–sulfur cluster synthesis and as a co-factor for awide variety of enzymes.Most of the iron in vertebrates is found in hemoglobin in red blood cells and iron deficiency anemia is a significant medical problem. Iron,...

Adverse effects of dietary fructose.

The consumption of fructose, primarily from high-fructose corn syrup (HFCS), has increased considerably in the United States during the past several decades. Intake of HFCS may now exceed that of the other major caloric sweetener, sucrose. Some nutritionists believe fructose is a safer form of sugar than sucrose, particularly for people with diabetes mellitus, because it does not adversely affe...